As I stirred the bubbling pot of garlic butter and ground beef, a wave of nostalgia washed over me, instantly transporting me back to cozy family dinners. There’s something undeniably comforting about Cheesy Penne with Garlic Butter Ground Beef—this dish is not just a meal, but a warm embrace on a hectic weeknight. With just a handful of ingredients and a quick prep time, it’s an ideal solution for those of us who crave home-cooked goodness without the fuss. This recipe lets you customize your favorite flavors while delivering that rich, creamy satisfaction we all adore. Think tender penne enveloped in a luscious cheese sauce, paired with robust ground beef—comfort food at its finest. Ready to create a dinner that brings comfort and joy to your table? Let’s dive into this delightful culinary adventure!

Why is this dish a must-try?
Comforting and soul-soothing, Cheesy Penne with Garlic Butter Ground Beef brings a homey warmth to any table. Quick and easy, this dish can be whipped up in just 30 minutes, making it perfect for busy weeknights. Customizable ingredients mean you can easily tailor it to your dietary preferences, whether opting for leaner proteins or extra veggies. Savory flavor from the garlic butter and rich cheese sauce creates a deliciously satisfying experience. Pair it with a refreshing side salad or some crispy garlic bread, and you have a meal that’s sure to impress family and friends!
Cheesy Penne with Garlic Butter Ground Beef Ingredients
For the Pasta
• 12 oz penne pasta – This is the main carbohydrate base; you can substitute with any preferred pasta shape like rigatoni or rotini.
For the Beef Mixture
• 1 lb ground beef – This provides protein and flavor; opt for lean ground beef to make it a lower-calorie option.
• 2 tablespoons olive oil – Used for cooking the ground beef; any cooking oil will work well in its place.
• 4 cloves garlic, minced – Infuses the dish with aromatic flavors; fresh garlic is always preferred for the best taste.
• 1 teaspoon Italian seasoning – Provides herbal notes; a mix of dried herbs can be used if Italian seasoning isn’t available.
• Salt and black pepper to taste – Essential for enhancing the overall flavor.
For the Creamy Sauce
• 3 tablespoons unsalted butter – Adds richness and flavor; olive oil can be a lighter alternative.
• 1 cup whole milk – Creates a creamy sauce; low-fat milk can reduce calories without sacrificing too much creaminess.
• 1 cup shredded cheddar cheese – The main cheese element for creaminess; feel free to replace it with your favorite cheese.
• ½ cup grated Parmesan cheese – Adds a salty depth to the sauce; cream cheese is a good alternative for creaminess.
• ½ cup sour cream – Enhances the dish’s creaminess and tanginess; light sour cream works as a good substitute.
For the Garnish
• Fresh parsley, chopped (optional) – Adds color and freshness to the dish upon serving; omit if you’re short on time!
With these ingredients, you’ll be well on your way to crafting an unforgettable Cheesy Penne with Garlic Butter Ground Beef that warms the heart and soul. Enjoy!
Step‑by‑Step Instructions for Cheesy Penne with Garlic Butter Ground Beef
Step 1: Cook the Penne Pasta
Begin by boiling a large pot of salted water over high heat. Once the water reaches a rolling boil, add the 12 oz of penne pasta and cook according to the package instructions until al dente, typically about 8-10 minutes. Once done, drain the pasta in a colander and set it aside while keeping it warm.
Step 2: Sauté the Ground Beef
In a large skillet, heat 2 tablespoons of olive oil over medium heat. Once the oil shimmers, add 1 lb of ground beef and cook, breaking it apart with a spatula. Sauté the beef until browned and fully cooked, which should take around 5-7 minutes. Drain any excess fat, then lower the heat slightly for the next step.
Step 3: Infuse the Garlic Butter
Reduce the heat to medium-low, then add 3 tablespoons of unsalted butter and 4 minced garlic cloves to the skillet with the ground beef. Stir the contents together, cooking for 1-2 minutes until the garlic becomes fragrant and golden, taking care not to burn it. This will create a delicious base for your Cheesy Penne with Garlic Butter Ground Beef.
Step 4: Season the Mixture
Sprinkle 1 teaspoon of Italian seasoning, along with salt and black pepper to taste, into the skillet. Stir until the seasonings are evenly distributed among the ground beef mixture. This step enhances the flavor profile of your dish, making it even more comforting and savory.
Step 5: Prepare the Creamy Sauce
In a separate saucepan, warm 1 cup of whole milk over low heat, stirring occasionally. Gradually add 1 cup of shredded cheddar cheese and ½ cup of grated Parmesan cheese, mixing until fully melted and smooth. Once the cheese has integrated into the milk, introduce ½ cup of sour cream into the sauce, stirring until combined seamlessly and creamy.
Step 6: Combine Everything Together
Add the drained penne pasta to the skillet with the beef mixture. Gradually pour the creamy cheese sauce over the top, stirring gently to coat the penne and ground beef evenly. This ensures every bite of your Cheesy Penne with Garlic Butter Ground Beef is packed with flavor and creaminess.
Step 7: Heat and Meld the Flavors
Allow the combined mixture to cook on low heat for an additional 2-3 minutes. This short cook time helps meld the flavors beautifully. Keep stirring occasionally to ensure nothing sticks to the bottom of the skillet. Adjust the seasoning with more salt and pepper if needed during this final step.
Step 8: Garnish and Serve
Once the flavors have melded perfectly, remove the skillet from the heat. If desired, sprinkle freshly chopped parsley over the Cheesy Penne with Garlic Butter Ground Beef for an inviting touch. Serve immediately while it’s hot and enjoy the comforting warmth of this delightful recipe.

Make Ahead Options
These Cheesy Penne with Garlic Butter Ground Beef are perfect for busy weeknights, allowing you to enjoy homemade comfort without the last-minute rush! You can prepare the beef mixture and cheese sauce up to 24 hours in advance. Simply cook the ground beef and garlic butter mixture, and then make the creamy cheese sauce; let both cool before refrigerating in airtight containers. When you’re ready to serve, boil the pasta, combine it with the previously prepared mixture, and warm everything on the stove for 5-7 minutes. This simple prep ensures your meal remains just as delicious and satisfying while saving you precious time during hectic evenings!
Cheesy Penne with Garlic Butter Ground Beef Variations
Feel free to explore delightful twists on this comforting dish, allowing your kitchen creativity to shine!
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Lean Protein: Swap ground beef for ground turkey or chicken for a lighter yet equally flavorful option.
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Veggie Boost: Stir in sautéed spinach, bell peppers, or mushrooms for a nutritious boost and added texture.
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Different Cheeses: Try mozzarella for a melty, stretchy texture, or gouda for a unique, smoky flavor profile.
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Creamy Alternatives: Replace sour cream with Greek yogurt for a tangy twist while keeping it creamy.
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Spice It Up: Add red pepper flakes for a subtle kick or diced jalapeños for a bolder heat level.
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Herb Infusion: Enhance the flavor by incorporating fresh herbs like basil or thyme in place of Italian seasoning.
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Whole-Grain Pasta: Use whole wheat or gluten-free penne to accommodate dietary needs while adding a different texture and flavor.
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Nutty Flavor: Mix in a spoonful of toasted pine nuts or walnuts for a delightful crunch that complements the creaminess of the dish.
By tweaking these ingredients, you’re not just making a meal, but crafting an experience. It’s all about what brings you joy at your table! For added inspiration, you might also enjoy exploring our other comforting dishes, like Creamy Mushroom Pasta or Garlic Butter Shrimp. Happy cooking!
How to Store and Freeze Cheesy Penne with Garlic Butter Ground Beef
Fridge: Store leftovers in an airtight container and refrigerate for up to 3 days. Make sure to let it cool completely before sealing to minimize moisture buildup.
Freezer: For longer storage, freeze the dish in an airtight container or freezer bag for up to 3 months. Let it cool completely before freezing to maintain texture.
Reheating: When ready to enjoy, reheat in a skillet over medium heat, adding a splash of milk to restore creaminess and prevent drying out. Stir occasionally for even heating.
Tip: This easy-to-make Cheesy Penne with Garlic Butter Ground Beef is perfect for meal prep, ensuring comfort food is always on hand!
Expert Tips for Cheesy Penne
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Perfect Timing: Begin cooking your penne pasta just before sautéing the ground beef. This way, they’ll finish at about the same time, ensuring everything is hot and fresh.
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Creamier Sauce: If you desire an even creamier texture for your Cheesy Penne with Garlic Butter Ground Beef, reserve a bit of pasta cooking water. Mix it into the cheese sauce gradually until you reach the desired creaminess.
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Avoid Garlic Burn: Keep an eye on the minced garlic while it cooks, as it can burn quickly. You want it fragrant and golden, not brown. Burnt garlic can turn bitter, affecting the whole dish.
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Customize Flavor: Don’t hesitate to get creative! Add sautéed vegetables like bell peppers, spinach, or mushrooms to introduce nutrition and taste without compromising the comfort of the recipe.
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Storage: If you have leftovers, store them in an airtight container in the refrigerator for up to three days. Reheat slowly, adding a splash of milk to keep the sauce smooth.
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Make it Lighter: Substitute ground beef with lean turkey or chicken, and use low-fat dairy products to enjoy a lighter version of this satisfying comfort food.
What to Serve with Cheesy Penne with Garlic Butter Ground Beef
A satisfying meal calls for delightful sides that enhance your dining experience.
- Garlic Bread: The crunchy, buttery goodness complements the creamy pasta beautifully, providing that beloved garlic flavor in every bite. It’s easy to make and a perfect vehicle for scooping up any leftover cheese sauce.
- Caesar Salad: Crisp romaine and tangy dressing offer a fresh contrast to the rich pasta dish. The crunch of croutons and the brightness of parmesan elevate your meal and balance the flavors.
- Steamed Broccoli: Adding a vibrant green element, this nutrient-rich side provides essential vitamins while adding a beautiful color to your plate. The mild flavor pairs well with the cheesiness of the main dish.
- Roasted Vegetables: A medley of seasonal veggies like zucchini, bell peppers, and carrots adds both nutrition and a sweet charred flavor. The texture contrasts nicely with the creamy penne, making every bite exciting.
- Italian Wine: A glass of Chianti or Sauvignon Blanc pairs perfectly with the savory garlic and beef flavors in the dish. The acidity helps remove heaviness, leaving you refreshed with each sip.
- Chocolate Mousse: End your meal on a sweet note with a rich chocolate mousse. Its light texture and sweetness provide a delightful contrast to the savory, cheesy penne. Plus, it’s a crowd-pleaser!

Cheesy Penne with Garlic Butter Ground Beef Recipe FAQs
What should I look for when selecting penne pasta?
When selecting penne pasta, look for ones that have a firm texture and no dark spots, which can indicate age. The pasta should feel smooth to the touch and have a shiny appearance. I recommend checking the expiration date and opting for brands that you trust for the best cooking results.
How should I store leftovers of Cheesy Penne with Garlic Butter Ground Beef?
Store any leftovers in an airtight container in the refrigerator for up to 3 days. Be sure the dish cools to room temperature before sealing it to prevent condensation, which can make it soggy. Simply reheat in the microwave or on the stovetop with a splash of milk to restore its creaminess when you’re ready to enjoy it again.
Can I freeze Cheesy Penne with Garlic Butter Ground Beef?
Absolutely! To freeze, let the dish cool completely, then transfer it into an airtight container or a freezer bag, removing as much air as possible to avoid freezer burn. It can stay frozen for up to 3 months. When ready to eat, thaw it overnight in the fridge and reheat in a skillet over medium heat with a bit of milk for that creamy texture.
What if my garlic butter burns while cooking?
If your garlic burns, it can give a bitter taste to the dish, so watch it closely! If you notice it browning too quickly, turn off the heat immediately and transfer it to a cooler pan. You might need to start over with fresh garlic to ensure your Cheesy Penne with Garlic Butter Ground Beef remains flavorful and aromatic.
Can I use non-dairy substitutes in this recipe?
Yes! For a dairy-free version, you can substitute whole milk with almond or oat milk, and use vegan cheese alternatives for both cheddar and Parmesan. Sour cream can be replaced with a plant-based yogurt to retain that creamy texture. These swaps allow everyone to enjoy this delicious dish, regardless of dietary preferences!
Is this recipe suitable for those with gluten sensitivities?
Yes, you can easily make this dish gluten-free by opting for gluten-free penne pasta. There are many great options available that cook up just as well and pair beautifully with the garlic butter and cheese sauce. Enjoy your comfort food without worry!

Cheesy Penne with Garlic Butter Ground Beef for Cozy Nights
Ingredients
Equipment
Method
- Boil a large pot of salted water over high heat. Add the penne pasta and cook until al dente, about 8-10 minutes. Drain and set aside.
- In a large skillet, heat olive oil over medium heat. Add ground beef and cook until browned, about 5-7 minutes. Drain excess fat.
- Add unsalted butter and minced garlic to the skillet. Cook for 1-2 minutes until fragrant.
- Stir in Italian seasoning, salt, and black pepper to the skillet, ensuring even distribution.
- In a separate saucepan, warm milk over low heat. Gradually stir in cheddar cheese and Parmesan until melted. Add sour cream and mix until creamy.
- Add the drained penne to the skillet and pour the cheese sauce over, stirring to coat evenly.
- Cook the combined mixture on low heat for 2-3 minutes to meld flavors. Stir occasionally.
- Remove from heat and garnish with parsley, if desired. Serve immediately.

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